Several protesters, some chanting anti-KKK messages and "Black Lives Matter" messages, interrupted the rally and were forcibly ushered out of the hangar at Lakefront Airport.
The billionaire businessman stopped addressing the audience at several points to order police to remove protesters.
Trump's rally in Louisiana took place a day before the state holds its Republican primary on Saturday (March 5) where he is expected to extend his lead when a total of 155 delegates are at stake as Kansas, Louisiana, Maine and Kentucky go to the polls which are called Super Saturday.
Nationally, Trump has the support of 41 percent of Republican voters, compared to 19 percent who back Cruz and 16 percent who back Rubio, according to Reuters/Ipsos polling data.