Insurgents from the terror group were killed by troops of the Kurdish YPG militia in Hasaka, while US-backed coalition airstrikes have continued to pound ISIS's positions.
As a result, 70 villages have been wrested from the terrorists control according to figures released by the London-based Syrian Observatory for Human Rights.
Also killed in the clashes were five members of the YPG militia, including a foreign soldier, it was claimed.
News of the setbacks for ISIS comes after militants abducted more than 150 christian people during dawn raids in Hasaka, last weekend.
ISIS militants abducted at least 150 Christians from villages in the north-east of Syria. Many of those taken were women and the elderly, according to Reuters.
The province of Hasaka is next to the Iraqi borderlands, where members of the minority Yazidi community were oppressed by ISIS last year.
ISIS in Iraq also losing ground. Yesterday Iraqi allied forces liberated al-Baghdadi in Anbar province.