"A man wearing an explosive belt boarded a public minibus in Choueifat and blew himself up," Marwan Charbel told Lebanon's Mayadeen television channel.
He said at least one person was killed in the blast, but it was unclear if that was in addition to the suicide bomber.
Choueifat lies south of Beirut, not far from the suburbs of the city, which have been targeted in multiple bomb attacks in recent months.
It is home to a mixed Christian and Druze population.
Footage from the scene broadcast on Lebanese television showed the mangled remains of a vehicle surrounded by shards of glass and other material in the middle of the road.
The blast comes after at least four people were killed in a suicide bombing on Saturday in the eastern town of Hermel.
Lebanon has been hit by a string of bomb attacks in recent months, many targeting areas sympathetic to Hezbollah Resistance.
Foreign backed terrorist groups believed to be linked to those fighting in Syria have claimed responsibility for most of the attacks.
But while the blasts have apparently targeted the group, the victims of the attacks have been almost exclusively civilians.
NJF/NJF