The party's central committee "held a lengthy meeting... on Monday morning," at which "a new national leadership was chosen," the Baath party website said on Monday.
The website published the names of 16 members of the new leadership, which included none of the party's old chiefs with the exception of President Assad.
The website said Assad would remain the party's secretary general.
Among those newly elected to the leadership are parliament chief Jihad al-Laham and Prime Minister Wael al-Halqi.
Monday's meeting of the party's central committee is the first since 2005, when much of the previous old guard was replaced.
Late Syrian president Hafez al-Assad became the secretary of the Syrian Regional Command of the party in 1970, and Secretary General of the National Command in late 1970.
Bashar al-Assad became the Regional Secretary of the party in Syria after his father's death in 2000.
SHI/SHI