"No one in Turkey has the right to hurl random accusations at Syria regarding the explosions that occurred in Turkey yesterday (Saturday)," Syrian Information Minister Omran al-Zoabi said.

"Syria would never do such a thing," he said, according to state SANA news agency.

Despite lacking any evidence at the time, Turkey was quick to blame the Syrian regime for two massive car bombs that killed 46 people in a town on the Syrian border.

"The Turkish government should be held responsible for what happened ... It has turned the border areas into a center for international terrorism," said al-Zoabi.

Turkey has been a strong supporter of the insurgency in Syria and a vocal critic of the government of President Bashar al-Assad whom it has repeatedly called on to leave.

"Recep Tayyip Erdogan has to step down. He must not build his glory on the blood of Turks and Syrians," al-Zoabi added, referring to the Turkish prime minister.