A well-known Saudi rebel called Abu al-Barra has been among the deaths.
The army also on Wednesday made advancements against the foreign-backed militants in the western city of Homs, gaining control of the city’s central district of Wadi al-Sayeh.
In Hama Province, government forces killed or captured a large number of militants during a separate operation on Wednesday.
The army also confiscated a significant quantity of weapons, ammunition and medical equipment.
Syria has been struggling with a US-backed insurgency which began in March 2011 as a protesting movement but turned to be a cover for terrorist groups including al-Qaeda and al-Nusra Front.
On Tuesday, US officials said that the White House is going to directly arm the militants to topple Syrian President Bashar al-Assad’s government.