Syria’s state television reported on Sunday that a car bomb had gone off at the Bilal Mosque near the capital’s Tahrir Square.
It said security forces had chased two other explosives-laden vehicles and detonated their explosives before they reached their targets.
Two booby-traps were also set off near the city’s al-Baitarah Square and Shuhada’ School.
A mortar round further landed in the area between the al-Saadat and Bab al-Salam neighborhoods, while several others hit the Bab Touma Borough and Baghdad Square at the capital’s al-Qadir Square.
It was not yet clear which of the incidents led to the casualties.
Damascus has been largely immune to rampant violence by foreign-backed terrorist groups, which have been operating in the country since 2011.