"The western states are stirring crisis to provide the security of the Zionist regime, and they are definitely making an irreparable miscalculation," Shamkhani said in a meeting with Syrian Parliament Speaker Mohammad Jihad al-Laham in Tehran on Tuesday.
"The recent experiences have shown that terrorism is a double-edged sword that will cleave its supporters' chests too," he added.
Shamkhani described Syria as the forefront of defending the Muslim territories against the Zionist regime and Takfiri terrorism, and said weakening Syria will exacerbate the security situation in all the neighboring states and the region.
Laham, for his part, expressed regret over the lack of a serious global resolve and determination to fight terrorism, and blasted the UN and the UN Security Council for keeping mum on the Takfiri groups' crimes and mass execution of innocent people.
In relevant remarks in 2013, Iranian Ambassador to Beirut Qazanfar Roknabadi blasted the US and its allies' warmongering policies against Syria, saying that they have planned a war Damascus in a bid to protect Israel's security.
"Safeguarding the Zionist regime's security is the main goal of the warmongers in the region," Roknabadi said in a meeting with the World Armenians Archbishop Jasliq Aram in Beirut.
He further reminded the world public opinion and most governments' opposition to the war against Syria, and said today religious leaders bear the important responsibility of illuminating the public opinion in support of the righteous sides in the world, especially in the Syrian issue, and emphasizing the necessity of opposition to the use of force against that country.