Yemeni military sources said the airstrike was carried out in the provincial capital city of al-Bayda, situated 200 kilometers (about 124 miles) southeast of the capital, Sana’a, on Monday.
Reports say the victims were suspected al-Qaeda militants.
On May 18, a US drone targeted a truck in the al-Mahfad region of Abyan Province. Local officials confirmed the death of four people but said it was not clear if they were al-Qaeda militants.
Five people were also killed in two similar strikes in a mountainous area near Sana’a on May 16.
Four of the victims were killed in the first strike as they were riding a vehicle in the desert area of Oussab al-Ali, while the fifth victim died when a drone fired a missile that hit his house.
The United States has stepped up its killer drone operations in Yemen over the past few years.
Washington has come under fire for increasing the drone attacks in the country, where the people have held many demonstrations to condemn the violation of Yemen’s sovereignty.
According to the Washington-based think tank the New America Foundation, the US drone attacks in Yemen almost tripled in 2012, surging from 18 to 53.
US officials claim that the airstrikes target militants, but local sources say civilians have been the main victims of the attacks.
The US also conducts drone strikes in Afghanistan, Pakistan, and Somalia.