The executive order issued Thursday marked the second time the U.S. has sanctioned leaders of Venezuela's socialist government since Donald Trump became president this year. In February, the U.S. announced it was freezing the assets of Vice President Tareck El Aissami, accusing him of playing a major role in international drug trafficking.

Those blacklisted under the latest decree include Maikel Moreno, the president of the government-packed Supreme Court, as well as all seven justices who signed a ruling in late March nullifying congress. The ruling was later partially reversed amid a surge of international criticism, but it sparked a protest movement that has seen almost daily street demonstrations for nearly two months — sometimes violent unrest that recorded its 45th death Thursday.

"By imposing these targeted sanctions, the United States is supporting the Venezuelan people in their efforts to protect and advance democratic governance in their country," U.S. Treasury Secretary Steven T. Mnuchin said.

Venezuelan Foreign Minister Delcy Rodriguez decried the U.S. sanctions on Twitter as "outrageous and unacceptable." She said the order was one more example of U.S. attempts to destabilize Venezuela's government, adding that Maduro strongly backs the Supreme Court magistrates who are "victims of U.S. imperial power."