The holy shrine has suffered some damages after the attack.
Some local agencies released news over the martyrdom of a custodian of holy Shrine, but an official statement verifying the death toll has not released yet.
The holy shrine, located in southern suburb of Damascus, also suffered damages in an attack by terrorists in June 2012. A car bomb explosion was also occurred near an intersection leads up to the shrine in September, 2008.
Last month, a group of foreign-backed terrorists have also clashed with army troops near the shrine.
Syria has been gripped by deadly unrest since 2011. According to the United Nations, more than 90,000 people have been killed and millions of others displaced in the violence.
Damascus says the chaos is being orchestrated from outside the country, and there are reports that a very large number of the militants are foreign nationals.
The regime of Israel, along with the West and its other regional allies, are partners in supporting over two years of deadly militancy in Syria.