Police Superintendent Eddie Johnson said on Friday that the shootings that happened within 12 hours of each other in the South Shore neighborhood were mostly due to gang conflict.
"I'm angry and sick," Johnson said during a news conference. "You have my promise that CPD will utilize the full weight of our resources to go after the individuals responsible for yesterday's incidents."
In the latest incident, a vehicle pulled alongside a van late on Thursday and opened fire. A man and a woman were shot, and the van crashed into a pole.
About 3:30 pm, a gunman walked into a restaurant and shot two men to death. The victims were identified as Emmanuel C. Stokes, 28, and Edwin Davis, 32.
Two other men, Dillon and Raheem Jackson, fled the violence at the restaurant but both were shot and killed in different parking lots nearby.
A young woman, who identified herself as the Jackson brothers’ sister, screamed at officers to move the bodies out of the rain.
All four were pronounced dead at the scene, according to the Cook County medical examiner’s office.
The neighborhood’s first homicide of the day happened shortly after noon inside an apartment, where 26-year-old Patrice L. Calvin, who was four months pregnant, was found dead with a gunshot wound to the head.
The latest episode of gun violence happened days after President Donald Trump met with police union leaders from across the US at the White House.
The president specifically called out the gun violence in Chicago, which saw more than 700 murders last year.
"Last year in Chicago, 4,368 people were shot. Nearly 700 more have already been shot since January of this year, alone. I ask, what is going on in Chicago? What is going on? There is no excuse for it," Trump said on Tuesday.