According to reports, the explosion took place at 6:30 a.m. (0430 GMT) on Saturday, caused damage to the facade of the Italian mission's building and shook the nearby supreme court in central Cairo.
Medical sources said five people, including two police officers stationed near the Italian mission, sustained injuries in the incident.
The exact cause of the blast is still unknown.However,Egyptian media quoted unnamed security sources as saying that it was a car bomb attack.
No group has claimed responsibility for the incident so far.