According to Afghan officials, the deadly air raids targeted a Taliban militants’ hideout in the Deh Bala district of the troubled province on Wednesday night.
The deadly attacks came one day after at least 43 militants lost their lives in two separate US drone attacks in Nangarhar.
Hussain Mashriqwal, Nangarhar provincial police spokesman Hazrat, said that at least 18 people were killed in Achin District while 25 others lost their lives in Haska Mina District.
ISIL leader in Afghanistan, Shahidullah Shahid, who was formerly a spokesman for the Taliban in Pakistan, was among those slain in the Achin district, Afghan broadcaster TOLOnews reported.
Washington has recently stepped up its drone attacks in Nangarhar. With the latest fatalities, the death toll among militants from a week of US aerial assaults in the eastern province has suppressed 120.
The US employs unmanned aerial vehicles in an alleged bid to target terrorists in Yemen, Pakistan, Afghanistan, and Somalia. This is while local officials and witnesses say that the drone strikes have mostly left civilians dead over the past few years.
The United Nations and several human rights organizations have identified the US as the world's number one user of "targeted killings," largely due to its drone attacks in Afghanistan and Pakistan.